A research technician position is immediately available at San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Unit of Gene and neural stem cell therapy for Lysosomal Storage Diseases led by Dr. Angela Gritti.
The Institute
SR-Tiget was created in 1996 as a joint-venture between Fondazione Telethon and Ospedale San Raffaele (OSR), with the mission to perform cutting edge research on gene and cell therapy and to translate its results into therapeutic advances for genetic diseases. The Institute is located within the OSR campus, which includes a large multi-disciplinary research hospital, a biomedical research center, a university and also hosts several biotechnologies companies. Over the years, SR-Tiget has given a pioneering contribution to the gene and cell therapy field with relevant discoveries in vector design, gene transfer and gene editing strategies, stem cell biology, identity and mechanism of action of regulatory cells in immune responses and innate immune cells in cancer. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials, which have already treated >120 patients and led to the filing and approval of 2 novel advanced therapy medicines.
The position
We are looking for research technician, reliable, highly motivated, with eager to learn, enthusiastic, well organized and team player. Experience animal work is required, experience in basic molecular and cellular biology is appreciated, but not mandatory. The candidate will work as a part of a dynamic team investigating the development of novel in vivo and ex vivo gene therapy strategies to treat inherited lysosomal storage disorders and leukodystrophies.
Main tasks
- Manage animal colonies used in the lab, providing routine and technical care to animals for experimental use
- Communicate animal health or welfare problems to the Principal Investigator/lab members and, eventually, to the veterinary staff
- Perform genotyping (qPCR) for colony maintenance and selection of animals to be treated
- Maintain organization of cages, equipment, and facilities. Maintain inventory of storeroom supplies.
- Maintain paper and computerized animal records, use and maintenance of equipment.
- Assist other lab members with handling animals during surgery procedures
- Monitor treated animals for health and welfare
- Provide humane euthanasia to animals as needed to minimize pain and distress and for colony maintenance, according to established protocols
- Assist other lab members with tissue collection and processing as needed
- Assist other lab members with immunocytochemistry, immunofluorescence, molecular, and biochemical assays
Qualifications and skills
- Educational requirements: Degree of biomedical laboratory technician Bachelor’s degree or Master’s degree in the field of Life Sciences
- Technical skills:
- Prior experience with animal work
- High accuracy, reliability, precision
- Strong problem-solving skills
- High motivation to work in an international, fast-paced environment
- Excellent organization skills and time management
- Ability to work in a team and independently.
- Friendly, collaborative, pro-active mindset
- Good oral and written English skills (appreciated)
We offer
- 1-year renewable contract with a competitive salary depending on level of education, skills and years of experience.
Applications, including a CV and reference letters (appreciated), should be sent by e-mail to gritti.angela@hsr.it. Evaluation of applications/interviews will begin immediately and continue until the position is filled.
