A RESEARCH FELLOW position is immediately available in the group of ANNA VILLA at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.
The Institute
SR-Tiget was created in 1996 as a joint-venture between Fondazione Telethon and Ospedale San Raffaele (OSR), with the mission to perform cutting edge research on gene and cell therapy and to translate its results into therapeutic advances for genetic diseases. The Institute is located within the OSR campus, which includes a large multi-disciplinary research hospital, a biomedical research center, a university and also hosts several biotechnologies companies. Over the years, SR-Tiget has given a pioneering contribution to the gene and cell therapy field with relevant discoveries in vector design, gene transfer and gene editing strategies, stem cell biology, identity and mechanism of action of regulatory cells in immune responses and innate immune cells in cancer. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials, which have already treated >120 patients and led to the filing and approval of 2 novel advanced therapy medicines.
The position
We are looking for a motivated RESEARCHER to work on the bone marrow niche and immune reconstitution in immune disorders upon innovative pre-transplant conditioning regimens.
The project, funded by Ministero della Salute, will be focused on the evaluation of innovative pre-transplant conditioning regimens based on antibody drug conjugates (ADC) to specifically target hematopoietic stem/progenitor cells with the final goal to preserve the bone marrow niche and improve the immunological reconstitution. To this aim, we plan to characterize at phenotypical, functional, and molecular level both hematopoietic and non-hematopoietic compartments of bone marrow niche before and after conventional and innovative ADC conditionings in distinct mouse models of immune disorders.
Main tasks
- Multiparametric flow cytometry
- Multiplex ELISA
- RNA-Seq and transcriptomic analyses
- Cellular and molecula biology
- Animal Handling
Qualifications and skills
- Degree in biomedical science
- Previous laboratory experience are welcome
- High accuracy, reliability, precision
- Friendly, collaborative, pro-active mindset
- Good oral and written English
We offer
- 1-year renewable contract and the possibility to apply to a PhD program or a technician position
- Competitive salary depending on qualifications and experience
- A dynamic and stimulating scientific environment and the chance to work on excellent state-of-the-art facilities and infrastructures.
Applications, including a CV and the names and contact details of at least one referee, should be sent by e-mail to villa.anna@hsr.it and castiello.mariacarmina@hsr.it . Evaluation of applications/interviews will begin immediately and continue until the position is filled.
