Stress ossidativo e Malformazioni Cavernose Cerebrali (CCM): dalla comprensione dei meccanismi della malattia verso gli approcci terapeutici

4.7 Anni 2015/2020
418.966€ Totale Fondi

Le malformazioni cavernose cerebrali (CCM) sono malformazioni dei vasi sanguigni del cervello che colpiscono circa lo 0,3-0,5% della popolazione. Le CCM sono caratterizzate da capillari sanguigni dilatati e fragili (chiamati caverne) che possono causare emorragie cerebrali, attacchi epilettici e problemi neurologici. La diagnosi si effettua mediante risonanza magnetica e al momento non esiste una cura specifica per la malattia, a parte la rimozione chirurgica delle lesioni. Esiste una forma ereditaria della malattia che dipende da alterazioni in tre geni che codificano per proteine coinvolte nella formazione dei vasi sanguigni: CCM1, CCM2 e CCM3. Tuttavia, esperimenti in modelli animali hanno dimostrato che la perdita di funzione dei geni CCM non è una causa sufficiente per la formazione delle lesioni, suggerendo che siano eventi di stress che si generano localmente a contribuire all’insorgere della malattia. In circa il 47% delle forme ereditarie la malattia è causata da mutazioni del gene CCM1. Grazie a studi condotti in precedenza, abbiamo scoperto che il gene CCM1 è coinvolto nella prevenzione dei danni ossidativi cellulari, suggerendo che le lesioni da CCM possano derivare da una ridotta capacità della cellula di difendersi da eventi di stress ossidativo cellulare in specifiche regioni del cervello. Per comprendere in modo più approfondito i meccanismi alla base della malattia e verificare la nostra ipotesi ci avvarremo anche di collaborazioni nell’ambito della rete di ricerca multidisciplinare CCM_Italia (http://www.ccmitalia.unito.it). In particolare, utilizzando un approccio di ricerca integrata basato su studi sia in modelli cellulari e animali della malattia e sia in campioni chirurgici di lesioni CCM, le tre unità di ricerca coinvolte in questo progetto potrebbero fornire nuove informazioni sui meccanismi patogenetici della malattia e suggerire nuove strategie terapeutiche.

Pubblicazioni Scientifiche

2021 Expert opinion on drug delivery
Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM).
2020 Antioxidants (Basel, Switzerland)
Vitamin D Deficiency and the Risk of Cerebrovascular Disease.
2020 Antioxidants (Basel, Switzerland)
Vitamin D Deficiency and the Risk of Cerebrovascular Disease.
2021 JOURNAL OF CELL SCIENCE
Protein kinase Ca regulates the nucleocytoplasmic shuttling of KRIT1.
2021 Expert opinion on drug delivery
Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM).
2020 Antioxidants (Basel, Switzerland)
Vitamin D Deficiency and the Risk of Cerebrovascular Disease.
2021 JOURNAL OF CELL SCIENCE
Protein kinase Ca regulates the nucleocytoplasmic shuttling of KRIT1.
2020 Methods in molecular biology (Clifton, N.J.)
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
2021 JOURNAL OF CELL SCIENCE
Protein kinase Ca regulates the nucleocytoplasmic shuttling of KRIT1.
2021 Expert opinion on drug delivery
Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM).
2020 Antioxidants (Basel, Switzerland)
Vitamin D Deficiency and the Risk of Cerebrovascular Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
2020 Methods in molecular biology (Clifton, N.J.)
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
2020 Nanomaterials (Basel, Switzerland)
Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.
2020 CELLULAR SIGNALLING
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
2020 Nanomaterials (Basel, Switzerland)
Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.
2020 Antioxidants (Basel, Switzerland)
Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
2020 CELLULAR SIGNALLING
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
2020 Nanomaterials (Basel, Switzerland)
Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.
2020 Antioxidants (Basel, Switzerland)
Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
2020 CELLULAR SIGNALLING
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
2020 CELLULAR SIGNALLING
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
2020 Nanomaterials (Basel, Switzerland)
Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.
2020 Antioxidants (Basel, Switzerland)
Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
2021 JOURNAL OF CELL SCIENCE
Protein kinase Ca regulates the nucleocytoplasmic shuttling of KRIT1.
2021 JOURNAL OF CELL SCIENCE
Protein kinase Ca regulates the nucleocytoplasmic shuttling of KRIT1.
2021 Expert opinion on drug delivery
Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM).
2020 Antioxidants (Basel, Switzerland)
Vitamin D Deficiency and the Risk of Cerebrovascular Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
2021 JOURNAL OF CELL SCIENCE
Protein kinase Ca regulates the nucleocytoplasmic shuttling of KRIT1.
2020 Methods in molecular biology (Clifton, N.J.)
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease.
2020 Antioxidants (Basel, Switzerland)
Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
2020 CELLULAR SIGNALLING
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
2020 Nanomaterials (Basel, Switzerland)
Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.
2020 Methods in molecular biology (Clifton, N.J.)
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
2021 Expert opinion on drug delivery
Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM).
2020 Antioxidants (Basel, Switzerland)
Vitamin D Deficiency and the Risk of Cerebrovascular Disease.
2021 Expert opinion on drug delivery
Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM).
2020 Methods in molecular biology (Clifton, N.J.)
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
2020 Methods in molecular biology (Clifton, N.J.)
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
2020 Methods in molecular biology (Clifton, N.J.)
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
2020 Methods in molecular biology (Clifton, N.J.)
From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease.
2020 Antioxidants (Basel, Switzerland)
Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
2020 CELLULAR SIGNALLING
KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.
2020 Antioxidants (Basel, Switzerland)
Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations.
2020 Nanomaterials (Basel, Switzerland)
Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes.
2020 Methods in molecular biology (Clifton, N.J.)
Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.
2020 Methods in molecular biology (Clifton, N.J.)
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.
2020 Methods in molecular biology (Clifton, N.J.)
Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.
2020 Methods in molecular biology (Clifton, N.J.)
Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
2020 Methods in molecular biology (Clifton, N.J.)
Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
2018 ACS omega
Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.
2020 Methods in molecular biology (Clifton, N.J.)
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
2020 Methods in molecular biology (Clifton, N.J.)
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
2018 ACS omega
Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.
2020 Methods in molecular biology (Clifton, N.J.)
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
2018 ACS omega
Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.
2020 Methods in molecular biology (Clifton, N.J.)
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
2020 Methods in molecular biology (Clifton, N.J.)
Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.
2018 ACS omega
Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.
2020 Methods in molecular biology (Clifton, N.J.)
Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
2020 Methods in molecular biology (Clifton, N.J.)
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
2018 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
2020 Methods in molecular biology (Clifton, N.J.)
Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence.
2020 Methods in molecular biology (Clifton, N.J.)
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.
2018 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
2018 Data in brief
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.
2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.
2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.
2020 Methods in molecular biology (Clifton, N.J.)
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.
2018 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
2020 Methods in molecular biology (Clifton, N.J.)
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
2018 Data in brief
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.
2020 Methods in molecular biology (Clifton, N.J.)
Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.
2020 Methods in molecular biology (Clifton, N.J.)
Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.
2017 SCIENTIFIC REPORTS
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
2020 Methods in molecular biology (Clifton, N.J.)
Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.
2019 Antioxidants (Basel, Switzerland)
KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.
2020 Methods in molecular biology (Clifton, N.J.)
Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.
2017 SCIENTIFIC REPORTS
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
2018 ACS omega
Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.
2016 The international journal of biochemistry & cell biology
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
2019 Antioxidants (Basel, Switzerland)
KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.
2020 Methods in molecular biology (Clifton, N.J.)
Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.
2017 SCIENTIFIC REPORTS
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
2016 The international journal of biochemistry & cell biology
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
2019 Antioxidants (Basel, Switzerland)
KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.
2018 Free radical biology & medicine
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
2019 Antioxidants (Basel, Switzerland)
KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.
2016 Nanoscale
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
2019 Antioxidants (Basel, Switzerland)
KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.
2020 Methods in molecular biology (Clifton, N.J.)
Generation of CCM Phenotype by a Human Microvascular Endothelial Model.
2020 Methods in molecular biology (Clifton, N.J.)
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
2018 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
2018 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
2018 Data in brief
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.
2018 Free radical biology & medicine
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
2017 SCIENTIFIC REPORTS
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
2016 The international journal of biochemistry & cell biology
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
2016 Nanoscale
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
2016 Nanoscale
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
2018 NUTRIENTS
Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.
2019 Antioxidants (Basel, Switzerland)
KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.
2018 Data in brief
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.
2018 NUTRIENTS
Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.
2018 ACS omega
Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.
2018 Data in brief
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.
2018 Free radical biology & medicine
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
2018 OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
2017 SCIENTIFIC REPORTS
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
2018 Data in brief
Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.
2016 Rare diseases (Austin, Tex.)
Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.
2017 SCIENTIFIC REPORTS
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
2016 AUTOPHAGY
Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.
2016 The international journal of biochemistry & cell biology
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
2016 AUTOPHAGY
Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.
2018 Free radical biology & medicine
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
2016 The international journal of biochemistry & cell biology
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
2016 Nanoscale
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
2018 Free radical biology & medicine
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
2016 AUTOPHAGY
Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.
2018 NUTRIENTS
Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.
2016 Nanoscale
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
2016 Rare diseases (Austin, Tex.)
Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.
2018 NUTRIENTS
Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.
2016 Nanoscale
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
2016 The international journal of biochemistry & cell biology
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
2018 Free radical biology & medicine
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.
2018 NUTRIENTS
Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.
2016 Rare diseases (Austin, Tex.)
Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.
2016 Free radical biology & medicine
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
2016 Free radical biology & medicine
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
2016 AUTOPHAGY
Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.
2016 Rare diseases (Austin, Tex.)
Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.
2016 AUTOPHAGY
Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.
2016 AUTOPHAGY
Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.
2016 Free radical biology & medicine
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
2016 Free radical biology & medicine
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
2016 Free radical biology & medicine
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
2018 NUTRIENTS
Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.
2016 Free radical biology & medicine
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
2016 Rare diseases (Austin, Tex.)
Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.
2016 Rare diseases (Austin, Tex.)
Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.

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