Produzione di emoglobina in cellule Eritroidi da pazienti con Beta Talassemia alterando processi biomolecolari in grado di regolare l’espressione dei geni per le globine

Pubblicazioni Scientifiche

• AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

  Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-Mediated Induction of Proinflammatory Responses

• ANALYTICAL CHEMISTRY

  Direct Detection of Point Mutations in Nonamplified Human Genomic DNA

• ANNALS OF HEMATOLOGY

  A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

• BIOCHEMICAL PHARMACOLOGY

  Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development

• BIOMED RESEARCH INTERNATIONAL

  Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β-Globin Gene with the IVSI-6 Thalassemia Mutation

• BMC BIOCHEMISTRY

  Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines

• BMC BIOTECHNOLOGY

  UPF1 silenced cellular model systems for screening of read-through agents active on β039 thalassemia point mutation

• BMC MEDICAL GENETICS

  An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production

• CHEMBIOCHEM

  Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells

• CHEMMEDCHEM

  Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen

• CHEMMEDCHEM

  Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)

• COOLEY'S ANEMIA: NINTH SYMPOSIUM

  A preclinical approach for gene therapy of β-thalassemia

• CURRENT TOPICS IN MEDICINAL CHEMISTRY

  Dipeptide Inhibitors of Thermolysin and Angiotensin I-Converting Enzyme

• EPIGENOMICS

  miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs

• EPIGENOMICS

  Involvement of miRNA in erythroid differentiation

• EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

  Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells

• EUROPEAN JOURNAL OF PHARMACOLOGY

  C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells

• EUROPEAN JOURNAL OF PHARMACOLOGY

  Erythroid differentiation ability of butyric acid analogues: Identification of basal chemical structures of new inducers of foetal haemoglobin

• EXPERIMENTAL HEMATOLOGY

  Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin

• EXPERT OPINION ON BIOLOGICAL THERAPY

  Alternative options for DNA-based experimental therapy of β-thalassemia

• EXPERT OPINION ON BIOLOGICAL THERAPY

  Recent trends for novel options in experimental biological therapy of β-thalassemia

• EXPERT OPINION ON ORPHAN DRUGS

  Orphan Drugs and Potential Novel Approaches for Therapies of β-Thalassemia: Current Status and Future Expectations

• EXPERT OPINION ON THERAPEUTIC PATENTS

  Recent patents on therapeutic applications of the transcription factor decoy approach

• EXPERT OPINION ON THERAPEUTIC PATENTS

  Peptide nucleic acids: a review on recent patents and technology transfer

• EXPERT OPINION ON THERAPEUTIC PATENTS

  Recent patents and technology transfer for molecular diagnosis of β-thalassemia and other hemoglobinopathies

• EXPERT REVIEW OF HEMATOLOGY

  Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia

• INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

  Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients

• INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

  Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells

• INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

  BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression

• INTERNATIONAL JOURNAL OF ONCOLOGY

  Peptide nucleic acids targeting miR-221 modulate p27Kip1 expression in breast cancer MDA-MB-231 cells

• JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

  Role of Slug transcription factor in human mesenchymal stem cells

• JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

  Effects of biomaterials for Lab-on-a-chip production on cell growth and expression of differentiated functions of leukemic cell lines

• JOURNAL OF MEDICINAL CHEMISTRY

  Psoralen Derivatives as Inhibitors of NF-κB/DNA Interaction: Synthesis, Molecular Modeling, 3D-QSAR, and Biological Evaluation

• JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

  Induction of erythroid differentiation and increased globin mRNA production with furocoumarins and their photoproducts

• JOURNAL OF TRANSLATIONAL MEDICINE

  A validated cellular biobank for β-thalassemia

• MOLECULAR DIAGNOSIS & THERAPY

  Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β0-Thalassemia Families with High Fetal Hemoglobin Levels

• MOLECULAR DIVERSITY

  Psoralen derivatives as inhibitors of NF- interaction: the critical role of the furan ring

• MOLECULAR MEDICINE

  Non-invasive fetal sex diagnosis in plasma of early weeks pregnants using droplet digital PCR

• MOLECULAR THERAPY-NUCLEIC ACIDS

  Efficient Delivery of MicroRNA and AntimiRNA Molecules Using an Argininocalix[4]arene Macrocycle

• MOLECULES

  trans-Resveratrol in Nutraceuticals: Issues in Retail Quality and Effectiveness

• PHARMACOLOGICAL RESEARCH

  Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions

• PLOS ONE

  Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients

• PLOS ONE

  Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells

• PLOS ONE

  Chemical-Induced Read-Through at Premature Termination Codons Determined by a Rapid Dual-Fluorescence System Based on S. cerevisiae

• PLOS ONE

  Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays