GENERATION OF ANIMAL MODELS OF HUMAN GENETIC DISEASES ASSOCIATED WITH DLX GENES ALTERATIONS; DEVELOPMENT OF NEW NON-VIRAL GENE THERAPY APPROACHES

Pubblicazioni Scientifiche

• 1999 JOURNAL OF DRUG TARGETING

  Optimisation of polyethylenimine-based gene delivery to mouse brain

• 2000 INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

  Multiple functions of Dlx genes

• 2001 ANNALS OF NEUROLOGY

  PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A

• 2001 NEUROBIOLOGY OF DISEASE

  The D355V mutation decreases EGR2 binding to an element within the Cx32 promoter

• 2000 GENE THERAPY

  Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes

• 2002 MOLECULAR AND CELLULAR NEUROSCIENCE

  Preferential transfection of adult mouse neural stem cells and their immediate progeny in vivo with polyethylenimine

• 2003 JOURNAL OF LEUKOCYTE BIOLOGY

  DLX genes as targets of ALL-1: DLX 2,3,4 down-regulation in t(4;11) acute lymphoblastic leukemias

• 1999 DEVELOPMENT

  Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5