FUNCTIONAL ANALYSIS OF MITOCHONDRIAL MYOPATHIES: A CELL BIOLOGY STUDY USING CYBRIDS AND NOVEL RECOMBINANT PROBES

Pubblicazioni Scientifiche

• 1997 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

  Chimeric calsequestrin and its targeting to the junctional sarcoplasmic reticulum of skeletal muscle

• 1998 EMBO JOURNAL

  The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum

• 1997 JOURNAL OF BIOLOGICAL CHEMISTRY

  BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+

• 1999 JOURNAL OF BIOLOGICAL CHEMISTRY

  Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells - Potential role for strategically located mitochondria

• 1997 EMBO JOURNAL

  Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells

• 1999 NATURE MEDICINE

  A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency

• 1997 JOURNAL OF CELL BIOLOGY

  Ca2+ homeostasis in the endoplasmic reticulum: Coexistence of high and low [Ca2+] subcompartments in intact HeLa cells

• 1999 MICROSCOPY RESEARCH AND TECHNIQUE

  Targeted recombinant aequorins: Tools for monitoring [Ca2+] in the various compartments of a living cell

• 1999 METHODS IN CELL BIOLOGY

  Targeting GFP to organelles

• 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME

  Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming

• 2000 JOURNAL OF CELL BIOLOGY

  Reduced loading of intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in Bcl-2-overexpressing cells

• 1998 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

  Calcium and organelles: A two-sided story

• 1998 EMBO JOURNAL

  Integrating cytosolic calcium signals into mitochondrial metabolic responses

• 1997 MOLECULAR BIOLOGY OF THE CELL

  Subcellular analysis of Ca2+ homeostasis in primary cultures of skeletal muscle myotubes

• 2000 NATURE CELL BIOLOGY

  High tide of calcium in mitochondria

• 1999 CELL CALCIUM

  Mitochondria as biosensors of calcium microdomains

• 1998 SCIENCE

  Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses