CONSTITUTIVE AND REGULATED EXPRESSION OF NORMAL AND MUTATED HUNTINGTIN IN ST14A STRIATAL CELLS: BIOLOGICAL AND BIOCHEMICAL ASPECTS

Pubblicazioni Scientifiche

• 2002 HUMAN MOLECULAR GENETICS

  Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

• 2003 NEWS IN PHYSIOLOGICAL SCIENCES

  Dysfunction of wild-type Huntingtin in Huntington disease

• 2000 JOURNAL OF NEUROSCIENCE

  Wild-type Huntingtin protects from apoptosis upstream of caspase-3

• 2001 FASEB JOURNAL

  Aberrant amplification of A(2A) receptor signaling in striatal cells expressing mutant huntingtin

• 2003 NATURE GENETICS

  Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

• 2001 SCIENCE

  Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

• 2002 JOURNAL OF BIOLOGICAL CHEMISTRY

  Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

• 2001 JOURNAL OF BIOLOGICAL CHEMISTRY

  Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

• 2000 HUMAN MOLECULAR GENETICS

  Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells