CHARACTERIZATION OF NON-CONSERVATIVE AMINO ACID VARIANTS OF THE INSULIN RECEPTOR SUBSTRATE-1 DETECTED IN PATIENTS WITH NIDDM

Pubblicazioni Scientifiche

• ENDOCRINOLOGY

  Tyr612 and Tyr632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

• EXPERIMENTAL CELL RESEARCH

  TGF-β1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells

• JOURNAL OF BIOLOGICAL CHEMISTRY

  Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin

• MOLECULAR ENDOCRINOLOGY

  Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains