BIOCHEMICAL AND GENETIC CHARACTERIZATION OF CVID

Pubblicazioni Scientifiche

• BIOLOGICAL CHEMISTRY

  Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor

• EUROPEAN JOURNAL OF IMMUNOLOGY

  Obligatory cross-talk with the tyrosine kinases assembled with the TCR/CD3 complex in CD4 signal transduction

• EUROPEAN JOURNAL OF IMMUNOLOGY

  Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR

• EUROPEAN JOURNAL OF IMMUNOLOGY

  Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects

• LEUKEMIA & LYMPHOMA

  Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias

• MOLECULAR IMMUNOLOGY

  Restoration of thymic development in an Lck-/- thymoma overexpressing ZAP-70

• ONCOGENE

  Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts