BIOCHEMICAL AND GENETIC CHARACTERIZATION OF CVID

Pubblicazioni Scientifiche

• 2000 EUROPEAN JOURNAL OF IMMUNOLOGY

  Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR

• 1999 BIOLOGICAL CHEMISTRY

  Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor

• 1999 LEUKEMIA & LYMPHOMA

  Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias

• 2000 EUROPEAN JOURNAL OF IMMUNOLOGY

  Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects

• 2000 ONCOGENE

  Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts

• 1999 EUROPEAN JOURNAL OF IMMUNOLOGY

  Obligatory cross-talk with the tyrosine kinases assembled with the TCR/CD3 complex in CD4 signal transduction

• 2000 MOLECULAR IMMUNOLOGY

  Restoration of thymic development in an Lck(-/-) thymoma overexpressing ZAP-70