A novel approach to the understanding and treatment of Hutchinson-Gilford Progeria Syndrome

Pubblicazioni Scientifiche

• AGEING RESEARCH REVIEWS

  Telomere transcription in ageing

• CELL DEATH & DISEASE

  Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)

• CELL DEATH AND DIFFERENTIATION

  DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue

• CELL REPORTS

  The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

• CELLULAR SENESCENCE

  DNA Damage In Situ Ligation Followed by Proximity Ligation Assay (DI-PLA)

• CELLULAR SENESCENCE

  DNA Damage In situ Ligation followed by Proximity Ligation Assay (DI-PLA) (vol 1896, pg 11, 2020)

• COMMUNICATIONS BIOLOGY

  Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

• EMBO REPORTS

  DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

• INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

  Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR

• INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

  A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres

• JOURNAL OF CELL SCIENCE

  DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

• JOURNAL OF CLINICAL INVESTIGATION

  CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer

• NATURE CELL BIOLOGY

  Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

• NATURE CELL BIOLOGY

  SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

• NATURE COMMUNICATIONS

  BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

• NATURE COMMUNICATIONS

  Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome

• NATURE COMMUNICATIONS

  Telomere damage induces internal loops that generate telomeric circles

• NATURE COMMUNICATIONS

  TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance

• NATURE COMMUNICATIONS

  Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

• NATURE REVIEWS MOLECULAR CELL BIOLOGY

  Cellular senescence in ageing: from mechanisms to therapeutic opportunities

• TRENDS IN GENETICS

  DNA Damage Triggers a New Phase in Neurodegeneration